Treating Cushing's disease in dogs
IN December last year, the US Food and Drug Administration (FDA) approved the first drug in more than 10 years to treat Cushing's disease in dogs.
Hyperadrenocorticism, commonly known as Cushing's disease, is a condition that results when the body produces too much of a hormone called cortisol. Cortisol is produced and stored by the adrenals, two small glands that sit on top of the kidneys. Dogs, cats, and horses, as well as humans, can get Cushing's disease. It is more commonly found in dogs than in cats or horses.
"Cortisol is one of the body's natural steroids," says Ann Stohlman, V.M.D., a veterinarian in FDA's Center for Veterinary Medicine, adding that a normal amount of cortisol is good. "It helps the body adapt in times of stress." Cortisol also helps regulate proper body weight, tissue structure, skin condition and other features of good health. But too much cortisol weakens the immune system, leaving the body vulnerable to other diseases and infections.
There are two common types of the illness. Most canine Cushing's disease occurs naturally and is either pituitary-dependent or adrenal-dependent. About 8085 percent of Cushing's is pituitary-dependent, meaning it is triggered by a tumor on the pituitary, a pea-sized gland at the base of the brain. The pituitary makes a number of hormones including adrenocorticotropic hormone (ACTH). The pituitary tumor causes overproduction of ACTH, which travels through the bloodstream to the adrenal glands, stimulating them to produce more cortisol than the body needs.
In the other 1520 percent of Cushing's dogs, a tumor in one or both adrenal glands produces excess cortisol. The type of Cushing's may determine what kind of treatment is prescribed. Veterinarians use blood tests to diagnose Cushing's and to differentiate between disease caused by the pituitary or by the adrenals. They may also use an ultrasound to help detect a tumor on an adrenal gland.
Cushing's disease typically occurs in middle-aged to older dogs. The disease develops slowly and the early signs are not always noticed. Symptoms in dogs include increased thirst, increased urination, increased appetite, reduced activity, excessive panting, thin or fragile skin, hair loss, recurrent skin infections, enlargement of the abdomen, resulting in a pot-bellied appearance.
Most veterinarians treat Cushing's disease with medication. The only way to cure Cushing's disease is to remove the adrenal tumor if the disease is adrenal-dependent and the tumor hasn't spread, says Stohlman. However, because of the complexity and risks of the surgery, most cases are treated with medication. Currently, surgery to remove a pituitary tumor is not an option.
Although Cushing's is typically a lifelong condition, the disease usually can be managed with medications. "It's important for a veterinarian to see the dog regularly and do blood tests," Stohlman says. "Monitoring the blood helps determine the right dose, which may need to be adjusted periodically."
Frequent blood tests are usually required in the first few months after starting treatment and then every few months after that, depending on the dog's response to treatment and tolerance to the medication.
Vetoryl (trilostane) capsules, the latest drug approved to treat canine Cushing's, is also the first drug approved to treat both pituitary-dependent and adrenal-dependent Cushing's in dogs. This prescription drug works by stopping the production of cortisol in the adrenal glands. In studies of the drug, the most common side effects were vomiting, lack of energy, diarrhea, and weight loss. Vetoryl should not be given to a dog that has kidney or liver disease, takes certain medications used to treat heart disease, or is pregnant.
The safety and effectiveness of Vetoryl were shown in several studies. Success was measured by improvements in both blood test results and physical symptoms (increased appetite and activity level, and decreased panting, thirst and urination).
Only one other drug, Anipryl (selegiline), is FDA-approved to treat Cushing's disease in dogs, but only to treat uncomplicated, pituitary-dependent Cushing's. Veterinarians have often used a human chemotherapy drug, Lysodren (mitotane) off-label to treat Cushing's in dogs. Lysodren destroys the layers of the adrenal gland that produce cortisol. It requires careful monitoring and can have severe side effects.
Off-label or extra-label, means veterinarians can legally prescribe human drugs to animals for uses not listed on the label, or for other species or at different dosage levels from those listed on the label. But because dogs may react unpredictably to human drugs, says Stohlman, so it's beneficial to have treatments available that have been studied in dogs and approved specifically for them.
"Treating Cushing's is a balancing act," Stohlman says, "but dogs with the disease can live a good life if they are monitored closely by a veterinarian and the owner is diligent about bringing the dog in for blood work and giving the medication as directed." - FDA